Vilitra is typically taken orally with water, about 25 to 60 minutes before anticipated sexual activity. Sexual stimulation is necessary for the medication to work effectively. The effects of Vilitra can last for about 4 to 6 hours, providing a window of opportunity for sexual activity. Inform your healthcare provider about your medical history, including any pre-existing conditions and medications you are currently taking. Certain medications and health conditions may interact with vardenafil, so it's important to ensure it is safe for you to use.