The closest airports to Port St. Lucie, Florida are the Palm Beach International Airport (PBI) and the Fort Lauderdale-Hollywood International Airport (FLL). PBI is approximately 50 miles south of Port St. Lucie, while FLL is around 80 miles to the southeast. Both airports offer a wide range of domestic and international flights, making them convenient options for travelers flying into or out of Port St. Lucie. Palm Beach International Airport serves as a major hub for several major airlines and offers numerous amenities such as rental car services, shops, restaurants, and lounges.